Three months after Achorn's Pharmacy left its longtime storefront on Main Street, the property has a prescription to remedy that vacancy.

Noted designer Jonathan Adler has signed a lease to open a new store in an approximately 2,200-square-foot space at 166 Main St. Adler has 20 stores around the nation, including outlets in Manhattan, Chicago, Miami and Los Angeles. The Westport outlet will be Adler's second store in Connecticut, joining its showroom on Greenwich Avenue in Greenwich.

The Adler stores' merchandise includes pottery, pillows and throws, furniture, rugs, lighting, bedding and bath items and bags and accessories.

"This is something Main Street doesn't have -- a high-class interior decorator with his type of furniture and fixtures," said HK Group Executive Vice President Mal Jacobson, who represented 166 Main St.'s owner during leasing negotiations. "I think it's going to be a great help to Main Street."

The Dartmouth Company's Fritz Kemerling co-brokered Jonathan Adler's lease with Jacobson.

The Main Street Jonathan Adler store is expected to open in late September or early October at the earliest, Jacobson added.

After decades on Main Street, Achorn's Pharmacy relocated in June to a new storefront in the Playhouse Square shopping center on Post Road East. Earlier this year, Harvey's Liquor Locker, another longstanding independent business on Main Street moved to the Compo Shopping Center on Post Road East.

The flight of independent retailers from downtown Westport's main thoroughfare is driven by their inability to afford the rents for prime retail spots in the town center.

pschott@bcnnew.com; 203-255-4561, ext. 118; twitter.com/paulschott